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Regulation of the expression of NKG2D ligands MULT-1 and H60 by MCMV

NK cells are of crucial importance in the early control of mouse cytomegalovirus (MCMV) infection. One of the most potent activating NK cell receptors is NKG2D that recognizes different MHC class I-like molecules. Up to now, three NKG2D ligands have been indentified in mice: RAE-1, H60 and MULT-1. We have previously shown that MCMV down-regulates NKG2D ligands from the surface of infected cells and identified MCMV m152/gp40 as a regulator of NKG2D ligands. Subsequent studies identified RAE-1 as the target for m152/gp40-mediated down-regulation. Recently, we identified two additional proteins encoded by viral m145 and m155 genes, which are responsible for the down-regulation of NKG2D ligands, MULT-1 and H60, respectively.

cytomegalovirus; innate immunity; NK cells; evasion; m145; m152; m155

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