engleski

Dynamics of IgM anti-HCV in acute and chronic HCV infection

Diagnosis of acute HCV infection remains a great problem. No etiologic marker has been proven useful to identify acute HCV infection – with exception of HCVAg in some special conditions. The purpose of this study was to determ dynamics of IgM anti-HCV in acute and chronic HCV infection and to determine its usefulness in diagnosis of acute HCV infection.We enrolled 11 patients with acute HCV infection determined by detection of HCVAg before appearance of anti-HCV (IgM or IgG) and approved thereafter by seroconversio. Also 35 patients with chronic HCV infection and with already existing anti-HCV were examinated. IgM anti-HCV were determined by commercially available enyime immunoassay and its titres were calculated as Index values. In all 11 patients mean value of IgM ant-HCV titres were much higher in acute HCV infection group than in chronic group. Such high titres lasted approximately during the first 2 months. In the next months mean value of IgM anti-HCV titres decreases and were approximately same in the both groups. IgM anti-HCV could be find in all acute but also in mayority of chronic HCV infection. During the early period of infection its titres are much higher than in chronic infection. Serial determination of IgM anti-HCV titres could help in diagnossis of acute HCV infection and allow decision of early treatment

HCV; acute infection; IgM anti-HC

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