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Anti-MOG IgG antibody- a diagnostic marker in different clinical types of MS

Myelin oligodendrocyte glycoprotein (MOG) is a highly immunogenic minor component on the outside surface of CNS myelin which is believed to be one of the autoantigens in multiple sclerosis. The aim of this study was to evaluate the diagnostic potential of anti-MOG IgG antibody levels in cerebrospinal fluid and serum of patients with relapsing-remitting multiple sclerosis, primary progressive multiple sclerosis and non-inflammatory neurological diseases as markers for the different clinical types of multiple sclerosis. The antibody responses to MOG were determined in paired samples of these differrent clinical groups by enzyme-linked immunoassay using a human MOG protein. The differences in levels were not statisticaly significant. The assay is not sensitive or specific enough to be used as a differential diagnostic tool for the clinical types of MS, nor for MS itself.

Myelin oligodendrocyte glycoprotein; Antibody; Multiple Sclerosis

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