engleski

Gastro-oesophageal reflux in relation to nutritional status and pulmonary function in children with cystic fibrosis

Aim: To evaluate the lung function and growth status of CF patients with or without gastro-oesophageal reflux (GOR). 27 CF children (age 3 month to 18 years, mean 7 years, 10 girls and 17 boys) were included. Nutritional status was evaluated based on anthropometrical assessments (weight, height and weight-for-height-index). All children underwent 24-h oesophageal pH monitoring and 14 (51%) of them were found to have GOR, defined as reflux index (RI) >10% for infants and RI>5% for other age groups. FEV1 was measured in 15 subjects old enough to perform the test. Severe pulmonary illness (FEV1 <40% of predicted value) was found in 3 patients (20%), moderate illness (FEV1 40-70% of predicted value) was found in 4 children (27%), and the rest had mild pulmonary affection (8 or 53%). Results for children with spirometry findings: Mean SD Range Age (years) 11.7 4.4 5-18 Weight/height index (%) 77.8 18.5 49.6-108.7 Mean pH 5, 39 0, 71 3.8-6.45 RI (%) 11.42 13.42 2-54.1 DeMeester score (normal <14, 71) 40.68 45.9 11-189.3 FEV1 (%) 67.4 24.65 21-101 Parameters describing GOR correlated well with patients&#8217; age: a negative correlation between age and mean pH was observed (p<0.001), as well as a positive correlation between age and RI, and age in relation to DeMeester score (p<0.002). This was not true for GOR and weight/height index, or for any parameter describing GOR in relation to FEV1 values. However, when only children with deteriorated lung function were evaluated (FEV1 <70%), a negative correlation to RI was determined (p<0, 05). These data indicate that GOR is partially age dependent and worsens with time, possibly contributing to more pronounced lung deterioration. Correlation was also proven between pulmonary function measured as FEV1 and growth expressed as weight/height index (p<0, 005).

gastro-oesophageal reflux

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