Effects of alpha-MSH on experimentally induced mucosal injury of rat gastrointestinal system (CROSBI ID 117494)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Konjevoda, Paško ; Štambuk, Nikola ; Tješić- Drinković, Duška ; Tješić-Drinković, Dorian ; Gotovac, Nikola ; Ježek, Davor ; Vikić-Topić, Dražen ; Votava-Raić, Ana
engleski
Effects of alpha-MSH on experimentally induced mucosal injury of rat gastrointestinal system
BACKGROUND AND PURPOSE: We investigated in vivo effects og alpha MSH on experimentally induced mucosal injury of rat gastrointestinal system. MATERIALS AND METODS: Cytoprotection excerted by alpha MSH in rat gastrointestinal system was evaluated by means of two standard experimental models suitable for pharmacological screening of new drugs: 1. ethanol induced gastric lesions, and 2. TNBS induced colitis. RESULTS AND CONCLUSION: Neuropeptide alpha-MSH exhibited strong, statistically significant and pharmacologically relevant gastrointestinal protection. additive protective effects were observed when alpha-MSH was administered in combination with met- enkephalin (another important proopiomelanocortin peptide).
alpha MSH ; rat ; gut
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Podaci o izdanju
Povezanost rada
Kliničke medicinske znanosti, Temeljne medicinske znanosti
