engleski

The impact of cognition of quality of life in non-demented Parkinson's disease patients

Background: It is known that motor symptoms in Parkinson&#8217; s disease (PD) patients have an impact on quality of life (QoL) while the role of cognitive functions is still controversial. Objective: To examine the effect of cognitive functions on QoL in non-demented PD patients. Patients and Methods: A total of 62 non-demented PD patients (Mini Mental State Examination > 25) were included. The assessment included Hoehn & Yahr scale (HY), Schwab & England disability scale (SE), Unified Parkinson Disease Rating Scale (UPDRS) and neuropsychological tests assessing visuospatial functions (the Hooper Visual Organization Test, Taylor Complex Figure Test, Trail A), executive functions (Trail B, the Stroop Test, Verbal and Category fluency), attention (Digit Span) and memory (Digit Symbol Test). QoL was rated with the PDQ-39, and depression with the Beck depression scores (BDS). The cut off score for severe depression was 17. Results: According to BDS score 38 patients were not severely depressed (NDP) and 24 were severely depressed (DP). DP had significantly worse PDQ-39 summary index scores than NDP (p<0.001). In DP, PDQ-39 scores correlated with depression (p<0.01), disease severity measured by HY (p<0.05), UPDRS part I (p<0.01), scores on tests assessing visuospatial functions (p<0.01), memory (p<0.01), executive functions (p<0.01) and attention (p<0.01). In NDP, PDQ-39 scores correlated with disease severity measured by HY (p<0.001) and motor functions assessed by motor part of UPDRS- III (p<0.05). Conclusion: Cognitive functions had an impact on QoL in DP patients, while in NDP QoL was primarily determinate by motor disability and disease severity.

Parkinson's disease; quality of life; depression

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