engleski

Dermatophagoides pteronyssinus allergen: case report.

Sublingual administration of immunotherapy (IT) has been effective among other local IT methods and is indicated in adult patients with allergic rhinoconjuctivis and/or asthma. Results of two years SLIT treatment with DP allergen is presented. A female patient, 21 years old, born in a village in the Međimurje region and now living in Zagreb, reported typical symptoms of perrenial rhinoconjuctivitis, which lasted for a year and were more intensive while staying in the village. Before the SLIT, prick test (PT) reactions (urtica) were to 6x6mm, Dermatophagoides farinae (DF) 4x3mm, Tyrophagus putrescentiae (TP) 5x5mm, (hystamine hydrochloride 1mg/ml 5x4 mm, buffer solution 0mm), total IgE(tIgE) level was >1000kU/L, specific IgE (sIgE) to DP 98, 2 kUA/L (+5) and to TP 9, 68 kUA/L (+3), nonspecific bronchoprovocation test showed bronchial normoreactivity (PC20FEV1>8mg/ml hystamine solution). SLIT was begun in May 1996. with DP allergen (ALK-Epipharm) standardized in 4 concentrations (50, 500, 5000, 50000 SQ-E/ml). Initial phase lasted for 20 weeks with maintenance dose achieved in 12 weeks. The only side effects were frequent sneezing and tongue itching during application of maintenance dose. In April 1997. SLIT was continued with maintenance dose for 6 weeks without side effects. Six months after beginning SLIT, PT reaction to DP was 3x3mm, tIgE 877kU/L, sIgE to DP 9, 78kUA/L (+3) and after 18 months PT reaction to DP was 5x5mm, tIgE 847kU/L, sIgE to DP 7, 51kUA/L(+3). Clinical symptoms were reduced to a complete absence of symptoms during stay in the town and only mild symptoms were present of the first day of stay in the village. Results indicate that SLIT is an affective, safe and simple method for administration of IT and should be used more frequently.

Atopy; sublingual immunotherapy; allergic rhinitis; Dermatophagoides

nije evidentirano