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izvor podataka: crosbi

Squamous cell lung carcinomas - the role of nm23-H1 gene (CROSBI ID 77690)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Herak Bosnar, Maja ; Pavelić, Krešimir ; Križanac, Šimun ; Slobodnjak, Zoran ; Pavelić, Jasminka Squamous cell lung carcinomas - the role of nm23-H1 gene // Journal of molecular medicine, 75 (1997), 8; 609-613-x

Podaci o odgovornosti

Herak Bosnar, Maja ; Pavelić, Krešimir ; Križanac, Šimun ; Slobodnjak, Zoran ; Pavelić, Jasminka

engleski

Squamous cell lung carcinomas - the role of nm23-H1 gene

This analysis of 32 pairs of human squamous cell lung carcinomas and normal matched control DNA demonstrates that loss of heterozygosity (LOH) is infrequent at the nm23-H1 locus, affecting only 2 of the 18 informative cases. Both LOH cases were in the tumor stage IIIA. One tumor was of poor and the other of moderate histological grade. These and an additional 34 tumor samples were also analyzed immunohistochemically for the presence of nm23-H1 protein. Of the 66 cases tested for the presence of nm23-H1 protein 54 were negative. Eight samples exhibited up to 35% positive cells (with weak immunostaining intensity) and four between 35% and 70% (moderate immunostaining intensity) ; no sample showed more than 70% positive cells. Noncancerous lung parts contained no nm23-H1 protein. nm23-H1 expression was independent of TNM stage, grade, tumor size, and patient"s survival. Two samples with LOH were negative for nm23-H1 protein. We therefore conclude that neither loss of heterozygosity of the nm23-H1 gene nor the intensity of specific protein expression are related to squamous cell lung carcinoma development and progression. [References: 18]

nm23-H1 gene; squamous cell lung carcinomas

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Podaci o izdanju

75 (8)

1997.

609-613-x

objavljeno

0946-2716

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost