Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Screening for Down's syndrome and neural tube defect in Croatia : A regional prospective study (CROSBI ID 118318)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Brajenović-Milić, Bojana ; Tišlarić, Dubravka ; Bačić, Josip ; Paravić, Jadranka ; Slivar, Anđelo ; Kapović, Miljenko ; Košec, Vesna ; Ristić, Smiljana ; Rajhvajn, Branko Screening for Down's syndrome and neural tube defect in Croatia : A regional prospective study // Fetal diagnosis and therapy, 13 (1998), 367-371

Podaci o odgovornosti

Brajenović-Milić, Bojana ; Tišlarić, Dubravka ; Bačić, Josip ; Paravić, Jadranka ; Slivar, Anđelo ; Kapović, Miljenko ; Košec, Vesna ; Ristić, Smiljana ; Rajhvajn, Branko

engleski

Screening for Down's syndrome and neural tube defect in Croatia : A regional prospective study

The purpose of this study was to investigate the efficiency of second-trimester maternal screening for Down's syndrome and open neural tube defects using alpha-fetoprotein and free beta-human chorionic gonadotropin as serum markers. 3, 188 women underwent testing between 14th and 22nd week of pregnancy. Of all tested patients, 25, 4% were > or = 35 years old. A cut-off risk of >/=1:250 for Down's syndrome and MS-AFP >/=2, 0 MoM for open neural tube defect were considered screen-positive. The detection rate for Down's syndrome was 77, 8% (7/9) with 8, 2% screen-positive rate (7, 9% false-positive rate). When evaluated separately, in patients younger than 35 and in those >/= 35 years old, the screen-positive rates were 3, 1 and 23, 3 %, respectively. A total of 52 (1, 6%) were found screen-positive for open neural tube defect. ; 2 cases of encephalocela and 1 case of gastroschisis were confirmed prenatally. The respectable number of cases with trisomy 21 identified in this study confirmes that routine mid-trimester screening for Down's syndrome including MS-AFP, free beta-hCG and maternal age is useful in identifying pregnancies at increased risk.

Down's syndrome screening; alpha-fetoprotein; free beta-human chorionic gonadotropin

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

13

1998.

367-371

objavljeno

1015-3837

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost