The influence of dopamine agonists and antagonists on gastric lesions in mice (CROSBI ID 118738)
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Podaci o odgovornosti
Sikirić, Predrag ; Rotkvić, Ivo ; Miše, Stjepan ; Križanac, Šimun ; Suchanek, Ernest ; Petek, Marijan ; Gjuriš, Veljko ; Geber, Juraj ; Tućan-Foretić, Milica ; Udovičić, Ivan ; Anić, Tomislav ; Balen, Ivan
engleski
The influence of dopamine agonists and antagonists on gastric lesions in mice
The dopamine agonist bromocriptine and L-dopa significantly inhibited whereas dopamine antagonist haloperidol aggravated the gastric lesions induced by pylorus ligation in mice as found earlier for rats. Furthermore, the successful use of a dopamine antagonist alone for the induction of gastric lesions also in mice was demonstrated, since the gastric lesions were induced by a single dose of haloperidol without any additional noxious treatment. Bromocriptine successfully inhibited both the gastric lesion-potentiating as well as the gastric lesion-inducing effect of haloperidol.
Dopamine agonists; Dopamine antagonists; Gastric lesions; (Mouse)
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