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Exposure to hyperbaric pressure alters ganglioside expression in rat liver following partial hepatectomy (CROSBI ID 513319)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija

Markotić, Anita ; Čikeš Čulić, Vedrana ; Tičinović Kurir, Tina ; Radić, Saša ; Zemunik, Tatijana ; Mesarić, Marko Exposure to hyperbaric pressure alters ganglioside expression in rat liver following partial hepatectomy // Periodicum Biologorum, vol 106, Supp 1. Zagreb, 2004. str. 119-x

Podaci o odgovornosti

Markotić, Anita ; Čikeš Čulić, Vedrana ; Tičinović Kurir, Tina ; Radić, Saša ; Zemunik, Tatijana ; Mesarić, Marko

engleski

Exposure to hyperbaric pressure alters ganglioside expression in rat liver following partial hepatectomy

Introduction: Remnant liver after partial hepatectomy (PH) demands an increased amount of oxygen to restore hepatic energy. Modulation of the ganglioside content of hepatocyte plasma membrane could provide a mean for upregulating cellular responsiveness to a variety of factors. Materials and Methods: Rat liver gangliosides were analysed by high perfomance thin layer chromatography (HPTLC) followed with immunostaining 54 h after PH. Non-operated and three different groups of operated rats were studied according to the hausing conditions before or after operation: recovering under normal ambient conditions after operation (1), treating with hyperbaric pressure before operation and recovering under normal ambient conditions (2 or preHB), and recovering under hyperbaric pressure after operation (3 or postHB). Results: Liver of preHB group showed the highest expression of ganglioside GD1a, a marker of a peculiar transition phase of liver regeneration. Same animals showed enhanced expression of the several gangliosides: GM2, GM1a, GD1b, GT1b, GalNAcGM1b, nLc4, nLc6 and nLc8. Conclusion: Since galactosyl- and N-acetylgalactosaminyltransferase catalyse final step of synthesys of GM2, GM1a, GD1b, GalNAcGM1b, nLc4, nLc6, and nLc8, our results point at possible role of galactosyl- and N-acetylgalactosaminyltransferase in regulation of the liver growth after PH.

gangliosides; hyperbaric oxygenation; immunostaining; partial hepatectomy

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Podaci o prilogu

119-x.

2004.

objavljeno

Podaci o matičnoj publikaciji

Periodicum Biologorum, vol 106, Supp 1

Zagreb:

Podaci o skupu

Fourth Croatian Congress of Pharmacology

poster

01.01.2004-01.01.2004

Split, Hrvatska

Povezanost rada

Kemija, Temeljne medicinske znanosti