engleski

Post-transplant lymphoproliferative disease (PTLD) in OLT patients in University Hospital "Merkur" Zagreb

PTLD is associated with EBV and CMV infection in SOT (solid organ transplantation). In University Hospital “ Merkur” Zagreb 108 liver transplantations have been performed. Two patients developed PTLD. The first was 54 years old men transplanted for HCV RNA cirrhosis Child C. 4 month after OLT he was CMV DNA positive and received ganciclovir 2x5mg/kg/twice daily 14 days i.v. and 3x1 gr. Peroral daily for 3 months. EBV DNA was negative. NHL-B cell lymphoma in abdominal lymph nodes was diagnosed and he received rituximab, but died within 2 months because of NHL progression. The other patient 56 old men was transplanted for alcoholic cirrhosis. 6 months after OLT CMC DNA was positive and the same schedule of ganciclovir was applicated. EBW DNA was negative. NHL-B cell lymphoma in liver graft and abdominal lymph nodes was diagnosed. He underwent rituximab and CHOP chemotherapy and is still alive. Conclusion: the risk of PTLD during the first year post-transplant in EBV negative, but CMV positive patients is higher even the therapy with ganciclovir was provided.

Liver transplantation; PTLD; lymphoproliferative disease

Transplant International. 2005 ; 18 (Suppl. 1)