Antioxidative system evaluation in patients with ischemic heart disease (CROSBI ID 468888)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Vukelić, Nada ; Vrkić, Nada ; Antoljak, Nataša ; Alfirević, Zdenka ; Topić, Elizabeta
engleski
Antioxidative system evaluation in patients with ischemic heart disease
The role of free radicals in the etiology and pathogenesis of cardiac diseases and in the development of atherosclerosis has recently attracted ever more interest. The body has a complex antioxidative mechanism of protection which eliminates or neutralizes the toxic effects of free radicals.The aim of the study was to determine the value of total antioxidative system (TAS) and activities of the superoxide dismutase enzyme (SOD) in patients with ischemic heart disease. Thirty patients were included in the study, i.e. 18 with myocardial infarction (IM) and 12 with angina pectoris (AP). Control group (C) consisted of 60 healthy age-matched subjects of both sex. Blood samples were obtained at 12, 36, 84 and 120 h after the onset of chest pain. Serum TAS values and erythrocyte SOD activity were determined (Randox Lab, UK). In both groups of patients, the mean TAS values were significantly lower compared to the control group (xIM=1.54 +/- 0.54, xAP= 1.44 +/-0.48, xC= 1.67 +/- 0.2 mmol/L, p is less than 0.05). The mean values of SOD activity were also significantly lower in both patients groups compared to the control group ( xIM=137.17 +/- 49, xAP=128.33 +/- 36.76, xC=160 +/- 31.6 U/L, p is less than 0.05). A reduced functional capacity of the antioxidative system is a complex disorder influencing the development of ischemic heart disease.
Antioxidative system; Ischemic heart disease; SOD
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Podaci o prilogu
277-277.
1998.
objavljeno
Podaci o matičnoj publikaciji
Neurologia Croatica, 47(Supp. 1), 5th Symposium on Intensive Care Medicine
Đurašin, Mirko
Zagreb: Croatian Neurological Society
0535-8842
Podaci o skupu
5th Symposium on intensive care medicine
poster
15.06.1998-18.06.1998
Brijuni, Hrvatska