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Changes in Macrophage Function During Chemotherapy (CROSBI ID 121764)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Vučković, Darinka ; Dorić, Miljenko Changes in Macrophage Function During Chemotherapy // Folia biologica (Praha), 43 (1997), 33-38-x

Podaci o odgovornosti

Vučković, Darinka ; Dorić, Miljenko

engleski

Changes in Macrophage Function During Chemotherapy

Antibiotics, in addition to killing or inhibiting the growth of microorganisms, may also affect the mechanism of host defence in many ways. Such effects may be clinically relevant especially in the case where an impairment of immunological function can be seen. We, therefore, decided to study the influence of penicillin G, cefotaxim, ceftazidime, streptomycin, and lincomycin on the function of phagocytes by using the macrophage adherence assay and the macrophage spreading assay. We also followed the concentrations of neopterin and interferon gamma (IFNgamma) in the plasma of mice treated with the above mentioned antibiotics. Changes in adherence of peritoneal macrophages were seen in mice treated with therapeutic doses of penicillin G and cefotaxim, after 2h of incubation. Cefotaxim and streptomycin in the usual therapeutic dose and ceftazidime in a fourfold higher dose influenced the capacity of peritoneal macrophages to spread on a glass surface. The same was seen with lincomycin when administered in the therapeutic dose and in a fourfold higher dose. In all the mice treated with antibiotics the concentration of IFNgamma was higher than in the control mice, while the reverse was seen concerning neopterin release, with an exception in mice treated with streptomycin.

macrophages; antibiotics; adherence; spreading; interferon gamma; neopterin

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Podaci o izdanju

43

1997.

33-38-x

objavljeno

0015-5500

2533-7602

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost