engleski

Decreased Ratio of Serum T3:rT3 in Patients with Hyperthyroidism

In 14 hyperthyroid patients serum T4:rT3 ratio was significantly lower (399&plusmn ; ; 20) than in the control subjects (572&plusmn ; ; 20 ; p<0.001). A similar patern was found for serum T3:rT3 ratio. In the hyperthyroid group the ratio was significantly lower (10.5&plusmn ; ; 0.5) than in the control group (12.5&plusmn ; ; 0.6 ; p<0.05). The data suggest that in hyperthyroidism the organism might shift conversion of T4 from biologically active T3 to poorly calorigenic rT3. It seems posible that the proportionately increased generation of rT3 than that may be a defence mechanism of the body, as it was found in systemic illnesses and starvation.

Thyroid hormones; Triiodothyronine; Reverse triiodothyronine; Hyperthyreosis

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