Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

The effects of kainic acid in rats with spontaneuos recurrent seizures (CROSBI ID 82848)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Dernovšek, Mojca Z. ; Sket, Dušan The effects of kainic acid in rats with spontaneuos recurrent seizures // General pharmacology, 31 (1998), 3; 447-449. doi: 10.1016/S0306-3623(98)00015-9

Podaci o odgovornosti

Dernovšek, Mojca Z. ; Sket, Dušan

engleski

The effects of kainic acid in rats with spontaneuos recurrent seizures

Rats with spontaneous recurrent seizures (SRS) were obtained bz injection of kainic acid (KA), !=mg/kg SC) to drug naive that regularlydevelop wet dog shakes followed by complex partial seiyures and status epilepticus. Three to five weeks later, the rats with menifest SRS were selected. The SRS were challenged with KA (10 mg/kg). The sizures induced in SRS rats by KA were similar to SRS regarding their clinical stage and duration. The frequency of seizure was, however, increased compared with the frequency of SRS in controls. vehicle treated SRS rats. The KA induced seizures in SRS rats differ behaviorally from Ka -induced seizures in naive rats, namelz, neither wet-dog shakes nor the status epilepticus could be induced. Repeated injectionof anequal dose of Ka, applied in SRS rats 1 day after the previous KA challenge did not induce seizures. The loss of seizure suspectibility to Ka was onlz temporary, as shown after 7days drug free periosd, when the repeated injection of KA regain its seizure triggering capacity. The results indicate that reactivity to the sizre-inducing agent kainic acid changes in rats with spontaneous recurrent seizures.

kainic acid; temporal lobe epilepsy; spontaneous recurrent seizures; postictal refractorines

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

31 (3)

1998.

447-449

objavljeno

0306-3623

10.1016/S0306-3623(98)00015-9

Povezanost rada

Kliničke medicinske znanosti

Poveznice
Indeksiranost