engleski

Effects of intrahippocampal injection of kainic acid on eeg and gross behavior in rats

Kainic acid (KA) is an excitatory glutaminergic agonist that induces epileptic seizures. The purpose of this study was to record EEG activity and the behavioral pattern changes after an intrahippocampal KA administration. Experiments were performed on adult Wistar rats. The animals were anesthetized and placed in a stereotaxic apparatus. Surface screw electrodes were placed over the frontal and parietal cortex. KA was administrated into the left dorsal hippocampus. The EEG activity was recorded in a basal conditions and 5, 10, 15, 30 and 60 minutes after the KA application. During this period complex behavioral pattern was also observed. EEG samples were digitized and subjected to computerized frequency analysis. The KA-induced excitatory changes in EEG activity were followed by complex behavioral syndrome that lasted for several hours. It has been concluded that intrahippocampal injection of kainate may be a useful experimental model for investigations of partial seizures with complex simptomatology (temporal lobe seizures disorders).

kainic acid; epileptic seizures; EEG; frequency analysis; rat

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