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Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis. (CROSBI ID 122992)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Bilić, Ranko ; Šimić, Petra ; Jelić, Mislav ; Štern-Padovan, Ranka ; Dodig, Damir ; van Meerdervoort, Halmar Pompe ; Ivanković, Davor ; Pećina, Marko ; Vukičević, Slobodan Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis. // International orthopaedics, 30 (2006), 2; 128-134. doi: 10.1007/s00264-005-0045-z

Podaci o odgovornosti

Bilić, Ranko ; Šimić, Petra ; Jelić, Mislav ; Štern-Padovan, Ranka ; Dodig, Damir ; van Meerdervoort, Halmar Pompe ; Ivanković, Davor ; Pećina, Marko ; Vukičević, Slobodan

engleski

Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis.

We randomly assigned 17 patients with scaphoid non-union at the proximal pole to three treatment groups: (1) autologous iliac graft (n=6), (2) autologous iliac graft + osteogenic protein-1 (OP-1 ; n=6), and (3) allogenic iliac graft + OP-1 (n=5). Radiographic, scintigraphic, and clinical assessments were performed throughout the follow-up period of 24 months. OP-1 improved the performance of both autologous and allogenic bone implants and reduced radiographic healing time to 4 weeks compared with 9 weeks in group 1. Helical CT scans and scintigraphy showed that in OP-1-treated patients sclerotic bone was replaced by well-vascularised bone. The addition of OP-1 to allogenic bone implant equalised the clinical outcome with the autologous graft procedure. Consequently the harvesting of autologous graft can be avoided.

osteogenic protein-1; BMP-7; scaphoid non-union; proximal pole sclerosis

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Podaci o izdanju

30 (2)

2006.

128-134

objavljeno

0341-2695

10.1007/s00264-005-0045-z

Povezanost rada

Kliničke medicinske znanosti

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