engleski

Effects of repeated growth-promoting doses of clenbuterol on hepatic function of female pigs

The effect of repeated administration of clenbuterol in a growth-promoting dose on hepatocellular integrity of female pigs was assessed by correlating histopathologic lesions in the livers of dosed pigs with changes in serum ALT, AST, GGT and AP activities.The experiment were carried out on 12 (6 control and 6 treated) female pigs 6-7 mo and 80-100 kg bw.Experimental animals were treated with 10 microgram clenbuteroll/kg bw iv twice daily for 25 d prior to being sacrificed.Blood and liver samples were collected.Treated animals had increased serum AP and ALT, whereas serum AST and GGT activities did not significantly change. Mild hyperplasia of biliary ducts, interstitial liver inflammation and and hydropic and vacuolar hepatocyte degeneration were observed.These findings indicate that repeated administration of growth-promoting doses of clenbuterol to female pigs adversely affect liver function.

clenbuterl; growth-promoting dose; pig; liver

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