engleski

Synthesis and antiproliferative activity of cyano and amidino substituted 2-phenyl-benzothiazoles

A series of new cyano, dicyano, amidino and diamidino substituted 2-phenyl-benzothiazoles were prepared. Mono- and dicyano substituted benzothiazoles were obtained by condensation of appropriate substituted benzaldehydes with o-aminothiophenol or p-cyano-o-aminothio-phenol. The appropriate amidines or diamidines were prepared by Pinner reaction. The compounds were tested against breast, prostate and lung cancer cell lines in a 72 hour cytotxicity assay. At 10 µ M, many of the compounds had activity equivalent to 2-(4-aminophenyl)benzothiazole ; however, a four of the compounds had significantly better activity particularly in the breast cancer model.

amidines ; cyano compounds ; benzothiazoles ; anticancer activity

nije evidentirano