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izvor podataka: crosbi

Synthesis of phenanthridinium bis-nucleobase conjugates, interactions with poly U, nucleotides and in vitro antitumor activity of mono- and bis-nucleobase conjugates (CROSBI ID 123212)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Tumir, Lidija Marija ; Piantanida, Ivo ; Žinić, Mladen ; Juranović Cindrić, Iva ; Meić, Zlatko ; Kralj, Marijeta ; Tomić, Sanja Synthesis of phenanthridinium bis-nucleobase conjugates, interactions with poly U, nucleotides and in vitro antitumor activity of mono- and bis-nucleobase conjugates // European journal of medicinal chemistry, 41 (2006), 10; 1153-1166-x

Podaci o odgovornosti

Tumir, Lidija Marija ; Piantanida, Ivo ; Žinić, Mladen ; Juranović Cindrić, Iva ; Meić, Zlatko ; Kralj, Marijeta ; Tomić, Sanja

engleski

Synthesis of phenanthridinium bis-nucleobase conjugates, interactions with poly U, nucleotides and in vitro antitumor activity of mono- and bis-nucleobase conjugates

Novel bis– nucleobase– phenanthridinium conjugates were synthesised and their aqueous solutions spectroscopically characterised. Bis– adenine conjugate revealed in aqueous solutions significantly more pronounced intramolecular aromatic stacking interactions than bis– uracil analogue. In contrast with previously reported poly A recognition by bis– uracil conjugate, recognition of complementary nucleotides and poly U was not observed due to the strong interference of bulk water with hydrogen bonding between nucleobases. The screening of anticancer activity on six human cell lines revealed that tethering of a nucleobase to phenanthridinium moiety diminished antiproliferative potential of phenanthridinium. However, among mono– nucleobase conjugates adenine derivative was found to be the most selective one (MiaPaCa– 2, Hep– 2).

phenanthridinium bis– nucleobase conjugates; nucleotides; polynucleotides; in vitro antitumor activity

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Podaci o izdanju

41 (10)

2006.

1153-1166-x

objavljeno

0223-5234

Povezanost rada

Kemija, Temeljne medicinske znanosti

Indeksiranost