engleski

Influence of Cytology Development on Frequency of Pre-Cancerous Lesions and Cervical Cancer in East Croatia, 1978-2001

Objective: to estimate the influence of cytology development, methods of precancerosa detection and cancer of the uterine cervix, to incidence of CIN 3 and cancer. Method: We analyzed, retrospectively, over four-year periods a total number of Pap smears, the number of detected CIN 3 and cervical carcinoma in the Clinical Hospital Osijek. The analyzed period is 1978-2001. For statistical data processing we used: linear trend equation, linear regression equation, Pearson’ s correlation coefficient, and Spearman’ s rank coefficient. Results. The number of examined Pap smears increased significantly in the analyzed period. The calculated linear trend shows an average four-year increase of 17283.35 smears. The number of detected CIN 3 increased accordingly. The calculated linear trend shows an average four-year increase by 45.03 and decrease of the rate of 0.07. A slight increase in cervical cancer was also noticed. The calculated linear trend shows an average four-year increase in cancer by 1.6 and decrease in the rate of 0.51. Analyses of cervical cancer by stages showed an increase in number of stage I and decrease of other stages. The calculated linear trend shows an average four-year increase of stage I by 4.94 or decrease in other stages of cervical cancer of 3.29 respectively. The rate of cervical cancer stage I decreased by 0.11 and of other stages by 0.39. Further analyses of the stage I showed that the linear trend of IA stage had an average four-year increase by 5.40 and decrease in stage IB of 0.48. The rate of the cervical cancer stage IA increased by 0.02, whereas the rate of IB decreased by 0.13. Conclusion: Cytology development in our country has resulted in detection of higher number of CIN 3 and the earliest stage (IA) of cervical cancer whereas the number of other stages (IB, II, III, IV) has decreased. However, a total number of cervical cancers haven’ t changed over the whole period. At the same time the rate of CIN 3 has decreased as well as the rate of all stages of cancer except from IA.

cytology; cervix; carcinoma cervicis; pre-cancerous; incidence; Croatia

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