engleski

Primary multicentric mixed carcinoma of the same breast

Objective: Multicentric-mixed carcinoma of the same breast is not frequent and FNA cytology is a very useful for distinquishing different type. Study design: In a 48-year-old woman FNAC of clinically, mammographically and ultrasound suspicious lesions (one tumour 1 cm in medial quadrant and another 1 cm inframammary of the right breast) was performed. Cytological diagnosis of breast cancer, of two different types was established. Pathologically the first tumour was diagnosed as ductal (negative for EP expresion, Katepsin D 24), and second as mixed carcinoma - lobular and ductal (Estrogen six, Progesteron 13, Katepsin D 24). Flow cytometric DNA analysis of breast tumor were done from paraffin-embedded samples. According to the DNA histograms, samples of ductal carcinoma were aneuploid with two peaks in Go phase and proliferative (S=21, 7%). Samples of mixed carcinoma (lobular and ductal) were diploid with high proliferative activity (S=30, 8%). Conclusion: The combination of FNAC and flow cytometric DNA analysis can be very useful for improving cytological diagnosis of breast cancer.

carcinoma of the breast; FNA

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