Cancer in the families of children with leukaemia and lymphoma (CROSBI ID 469281)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Roganović, Jelena ; Radojčić Badovinac, Anđelka ; Buretić-Tomljanović, Alena
engleski
Cancer in the families of children with leukaemia and lymphoma
Familial agregation has been reported for virtually every form of human cancer. Accordingly, many multiple-case families with haematological malignancies have been described and this has led to the suggestion of genetic susceptibility to these diseases. We conducted a family study of the occurrence of cancer in the relatives of 64 children affected by acute leukaemia and malignant lymphoma trearted at the Division of Haematology, Department of Paediatrics, University of Rijeka, Children's Hospital "Kantrida", in the perion from 1980 to1995. The information was otained from interviews with the parents of affected children regarding the occurrence and type of cancer in relatives. As often as possible, medical records and death certificates were sought for reported rumours and deaths. On the bases of the anamnestic data genealogical charts has been made. We found significant excess of cancer in the families of children affected by leukaemia and lymphoma. The higher frequency was obtainedfor the second generation relatives and maternal line. Independently of the age of the affected child, in most families, one or two additional family members had cancer. No typical tumor constellation was found, a specific hereditary pattern of cancer. The findings of this study suggest that genetic factors play an important role in the aetiology of haematological malignancies. Continued epidemiological and molecular genetic studies are needed to estimated precisely the inherited fraction of childhoodcancer and identify individuals at risk.
leukaemia; lymphoma; genealogy; hereditary
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Podaci o prilogu
134-134.
1997.
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objavljeno
Podaci o matičnoj publikaciji
5th Paediatric Alps-Adriaric Symposium : Abstracts ; u: Paediatria Croatica (ISSN 1330-1403 ) 4 (1997) (2)
Podaci o skupu
Paediatric Alps-Adriaric Symposium (5 ; 1997)
predavanje
04.06.1997-07.06.1997
Rijeka, Hrvatska