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Comparison of immunogenicity of recombinant and plasma derived hepatitis B antigen in guinea pigs

Four different preparations of hepatitis B antigen (HBsAg) were tested in parallel with respect to their ability to elicit anti-HBs in guinea pigs. We compared the effect of low doses od human plasma derived and recombinant HBsAg in purified forms or prepared as vaccines, respectively. The highest titre of anti-HBs developed was detected in guinea pigs immunized with plasma derived HBsAg, followed by the response in animals immunized with plasma derived vaccine. Purified recombinant antigen and recombinant vaccine exhibited poor immunogenicity compared with plasma derived antigen preparations.

HBsAg ; immunoassay ; guinea pig ; plasma-derived ; recombinant

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