N-glycosylation of Recombinant Therapeutic Glycoproteins in Plant Systems (CROSBI ID 123869)
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Podaci o odgovornosti
Balen, Biljana ; Krsnik-Rasol, Marijana
engleski
N-glycosylation of Recombinant Therapeutic Glycoproteins in Plant Systems
Transgenic plants have recently emerged as a promising system for low-cost and large-scale production of therapeutic proteins. Despite many advantages plants offer as hosts for expression of recombinant proteins, there are certain limitations caused by major structural differences between plant and mammalian N-linked glycans. Thus, the efforts are being made in order to eliminate, or at least minimize, plant-specific N-glycosylation as well as to supplement plant endogenous system with human glycosyltransferases to obtain "humanized" non-immunogenic N-glycans on plant-made pharmaceuticals aimed for human therapy.
N-glycosylation; transgenic plants; glycosyltransferases; sialic acid; recombinant protein; therapeutic glycoproteins
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