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izvor podataka: crosbi

N-glycosylation of Recombinant Therapeutic Glycoproteins in Plant Systems (CROSBI ID 123869)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Balen, Biljana ; Krsnik-Rasol, Marijana N-glycosylation of Recombinant Therapeutic Glycoproteins in Plant Systems // Food technology and biotechnology, 45 (2007), 1; 1-10-x

Podaci o odgovornosti

Balen, Biljana ; Krsnik-Rasol, Marijana

engleski

N-glycosylation of Recombinant Therapeutic Glycoproteins in Plant Systems

Transgenic plants have recently emerged as a promising system for low-cost and large-scale production of therapeutic proteins. Despite many advantages plants offer as hosts for expression of recombinant proteins, there are certain limitations caused by major structural differences between plant and mammalian N-linked glycans. Thus, the efforts are being made in order to eliminate, or at least minimize, plant-specific N-glycosylation as well as to supplement plant endogenous system with human glycosyltransferases to obtain "humanized" non-immunogenic N-glycans on plant-made pharmaceuticals aimed for human therapy.

N-glycosylation; transgenic plants; glycosyltransferases; sialic acid; recombinant protein; therapeutic glycoproteins

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Podaci o izdanju

45 (1)

2007.

1-10-x

objavljeno

1330-9862

Povezanost rada

Biologija

Indeksiranost