engleski

VEGF in inverted sinonasal papillomas

Although for inverted papillomas (IP) local aggressiveness and marked tendency to recur have been known for decades, association with squamous cell carcinoma (SCC) is still a subject of investigation since neither histologic feature nor local aggressiveness can be used as prognostic marker. According to our previous results and to results of other p53 and Ki67 immunohistochemistry have some diagnostic but little prognostic potential. We analyzed 50 cases of IP including 6 cases of synchronous SCC. The patients had diagnosed IP in the period from 1982 to 2005 at the Departments of Pathology, University in Zagreb, University of Osijek and the National Medical Center Budapest, Hungary. Immunohistochemistry for VEGF was performed according to manufacturers’ specification (Santa Cruz, USA). A PC based image analysis system (ISSA/SFORM, Vamstec, Zagreb) was used to determine the rate and intensity of nuclear staining. The histological pattern and intratumoral distribution of immunoreactivity was accessed together with the immunoreactivity of neighboring normal epithelium. Although the normal sinonasal epithelium shows VEGF immunoreactivity, the epithelium of both benign and malignant inverted papillomas demonstrated stronger reactivity following the histological pattern.

VEGF; inverted papillomas; immunohistochemistry

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