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Quantitative analysis of constitutive heterochromatin in children with acute lymphoblastic leukaemia (CROSBI ID 469438)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Roganović, Jelena ; Buretić-Tomljanović, Alena ; Radojčić Badovinac, Anđelka Quantitative analysis of constitutive heterochromatin in children with acute lymphoblastic leukaemia // Medical and pediatric oncology. 1998. str. 334-334

Podaci o odgovornosti

Roganović, Jelena ; Buretić-Tomljanović, Alena ; Radojčić Badovinac, Anđelka

engleski

Quantitative analysis of constitutive heterochromatin in children with acute lymphoblastic leukaemia

The biological role of the constitutive heterochromatin in the human genome is a subject of numerous speculations. Of the particular interest are the investigations in the group of the patients with malignant diseases, and the suggestion that heterochromatic variants increase the risk of malignant transformation. The aim of our study was to determine the correlation of quantitative changes of the constitutive heterochromatinand malignant transformation in children in acute lymphoblastic leukaemia. The length variability of the constitutive heterochromatine of chromosomes 1, 9 and 16 was analysed in 39 children with acute lymphoblastic leukaemia and in 21 healthy controls. The analysis was carried outon slides obtained by routine method of peripheral blood culture and stained for G-banding. The objective method of linear measuring was used. A statisticaly significant shorter lengthof the heterochromatic regions of chromosome 1 was found in the children with acute lymphoblastic leukaemia compaired with control group (p<0.001), while there was no differencein the heterochromatin segment length of chromosomes 9 and 16. These results suggest a possible relationship between the quantitative changes of the constitutive heterochromatin of the chromosome 1 and malignant transformation. In the children with acute lymphoblastic leukaemia haterochromatic variants might present a genomic instability, and the additional cytogenetic chenges are required to produce a malignant fenotype.

leukaemia; heterochromatin

U-5

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Podaci o prilogu

334-334.

1998.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Medical and pediatric oncology

London : Delhi: Wiley-Liss

0098-1532

Podaci o skupu

Meeting of the International Society of Pediatric Oncology (30 ; 1998)

poster

04.10.1998-08.10.1998

Yokohama, Japan

Povezanost rada

Javno zdravstvo i zdravstvena zaštita

Indeksiranost