engleski

Comparison of different solid-phase extraction materials for sample preparation in the analysis of veterinary drugs in water samples

This paper focuses on the study of different types of SPE materials that can be used for preconcentration of eight pharmaceuticals from water samples. The compounds studied were enrofloxacine, norfloxacine, oxytetracycline, trimethoprim, sulfamethazine, sulfadiazine, sulfaguanidine and penicillin G/procaine. Cartridges were tested on spiked water samples and the extraction efficiency was determined by thin-layer chromatography (TLC) CN-modified chromatographic plates with 0.05 M H2C2O4-methanol, 81+19, as mobile phase. Strata-X cartridges were proved to be the best type of SPE material for this group of pharmaceutical compounds. For that reason an SPE-TLC method with Strata-X cartridges and HPTLC plates was validated. The method has been applied to the determination of pharmaceuticals in production wastewater samples from pharmaceutical industry.

pharmaceuticals ; SPE cartridges ; colid-phase extraction (SPE) ; thin-layer chromatography (TLC) ; production wastewater ; validation

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