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izvor podataka: crosbi

Synthesis, crystal structure determination and antiproliferative evaluation of novel benzazoyl benzamides (CROSBI ID 124671)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Starčević, Kristina ; Ćaleta, Irena ; Cinčić, Dominik ; Kaitner, Branko ; Kralj, Marijeta ; Ester, Katja ; Karminski-Zamola, Grace Synthesis, crystal structure determination and antiproliferative evaluation of novel benzazoyl benzamides // Heterocycles, 68 (2006), 11; 2285-2299-x

Podaci o odgovornosti

Starčević, Kristina ; Ćaleta, Irena ; Cinčić, Dominik ; Kaitner, Branko ; Kralj, Marijeta ; Ester, Katja ; Karminski-Zamola, Grace

engleski

Synthesis, crystal structure determination and antiproliferative evaluation of novel benzazoyl benzamides

A series of benzazoyl-benzamides containing different substituents 7-17 were synthesized by condensation of 2-aminobenzazole derivatives 3a-6 with p-substituted benzoyl chlorides. All compounds were characterized by IR, 1H and 13C NMR, MS and elemental analysis. Crystal structure was determined for the compound 9. Some of the new synthesized compounds 7-17 were screened for antitumor activities. Based on presented in vitro screening results we may conclude that compounds 10, 15a, 15b and 16 showed accentuated cell growth inhibitory activity.

benzazoyl benzamides; synthesis; crystal structure; antiproliferative evaluation

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Podaci o izdanju

68 (11)

2006.

2285-2299-x

objavljeno

0385-5414

Povezanost rada

Kemija, Temeljne medicinske znanosti

Indeksiranost