Hyperbaric oxygenation improves motor deficit in spinal cord injured rabbits (CROSBI ID 469480)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Simonić, Ante ; Draganić, Pero
engleski
Hyperbaric oxygenation improves motor deficit in spinal cord injured rabbits
Spinal cord injury often results in nerve tissue damage followed by motor and sensory deficit. Hypoxia caused by spinal cord injury to nerve tissue damage and deterioration of neural function. The purpose of this study was to investigate the influence of hyperbaric oxygenation, a potent repressor of tissue hypoxia on motor activity of spinal cord injured rabbits. The study was carried ouit on adult rabbits 2.5-3.5 kg body weight. Medial dorsal lumar laminectomy was performed under pentobarbital anesthesia )30mg/kg i.v.) followed by the contusion of spinal cord rpovoked by a strike of 150 g cm, that resulted in spontaneously irreversible paraplegia in the experimental animals. The animals have been exposed to hyperbaric oxygenation immediately after the injury and during the eight subsequent days,at 2.2 ATE pressure of 99.5 - 0.5 % oxygen, lasting 45 minutes. Hind limb motor activity was controled daily, according to Tarlov 's system during the whole course of the experiment. The results of the experiment show that the hyperbaric oxigen diminished the motor deficit in the injured animals. A significant improvement of the motor deficit has been observed during the whole course of the experiment.
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Podaci o prilogu
57.38-x.
1998.
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objavljeno
Podaci o matičnoj publikaciji
Naunyn-Schmiedeberg's Arch Pharmacol (suppl) 2/358
IUPHAR
München: Springer
Podaci o skupu
XIIth International Congress of Pharmacology
poster
26.07.1998-31.07.1998
München, Njemačka