Electrochemical reduction of 4'-demicarosyl-10-hydro-11-dehydro-11-hydroxyimino-9-carbonyl-9-nor-8a,9seco-8a-aza-8a-homorelomycin, the novel seco compound from the class of tylosin (CROSBI ID 125378)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Mandić, Zoran ; Lopotar, Nevenka
engleski
Electrochemical reduction of 4'-demicarosyl-10-hydro-11-dehydro-11-hydroxyimino-9-carbonyl-9-nor-8a,9seco-8a-aza-8a-homorelomycin, the novel seco compound from the class of tylosin
The electrochemical reduction of 4'- demicarosyl-10-hydro-11-dehydro-11- hydroxyimino-9-carbonyl-9-nor-8a, 9seco-8a-aza- 8a-homorelomycin was investigated by cyclic voltammetry and preparative scale electrolysis. It has been found that oxime group is reduced by ECEC mechanism in a four-electron process. The resulting products of the reduction consisted of the corresponding alpha, beta- unsaturated amine and alpha, beta-saturated ketone. The rate determining step was identified to be the cleavage of N-O bond. In the acidic media the actual leaving group is water and in neutral and moderate basic media hydroxyde ion.
tylosin ; electroreduction of oxime ; cyclic voltammetry ; preparative scale electrolysis
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Podaci o izdanju
7 (1)
2005.
45-48
objavljeno
1388-2481
1873-1902
10.1016/j.elecom.2004.11.002
Povezanost rada
Kemija, Kemijsko inženjerstvo