engleski

Preparation of highly porous hydroxyapatite ceramics from cuttlefish bone

Scaffold of hydroxyapatite for further tissue-engineering application was produced by hydrothermal treatment of cuttlefish bone originated aragonite at 200 °C. Aragonite (CaCO_3) monoliths were completely transformed into hydroxyapatite after 48 hours of HT treatment. The substitution of CO_3^2- groups predominatly into the PO_4^3- sites of the Ca_10(PO_4)_6(OH)_2 structure was suggested by FTIR spectroscopy. SEM micrographs have shown that the interconnected hollow structure with pillars connecting parallel lamellae in cuttlefish bone is maintained after conversion. Specific urface area (S_BET) and total pore volume increased and mean pore size decreased by HT treatment.

scaffold; cuttlefish bone; hydroxyapatite; microstructure

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