Endemic nephropathy and exposure to mycotoxins (CROSBI ID 520097)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Peraica, Maja ; Domijan, Ana-Marija
engleski
Endemic nephropathy and exposure to mycotoxins
The occurrence of endemic nephropathy (EN) in rural population in regions without industry indicates the natural toxic compound as a causative agent. The mycotoxin theory of the development of EN is based on the similarities of pathological kidney lesions in patients with EN and that of pigs in Scandinavian countries. This fact focused the research of EN on the human exposure to the mycotoxin ochratoxin A (OTA), the causative agent of pig nephropathy. OTA is nephrotoxic and carcinogenic compound that fitted well with an unusually high incidence of upper urothelial tumors in patients with EN. In several studies OTA was found either more frequently or in higher concentrations not only in various commodities, but also in blood of persons in endemic region. However, OTA was found very frequently in healthy humans out of endemic region. Various mycotoxins are produced by same genera of moulds, but even one strain may produce different mycotoxins. The co-occurrence of OTA, citrinin and fumonisin B1 (FB1) was found in commodities from endemic regions in Bulgaria and Croatia. Therefore, the possibility of the exposure of humans in the endemic region to various mycotoxins and their combinations seems real. The literature data on combined toxic effects of OTA and other nephrotoxic mycotoxins, such as FB1, penicillic acid (PA), and citrinin, are rather scarce. We have studied the effect of OTA and FB1 on oxidative DNA damage in rat kidney measured with single cell gel electrophoresis (comet assay). In kidney of rats treated with either OTA or FB1 or their combinations tail length and tail intensity of comet assay clearly showed their synergistic genotoxic effect. This effect was seen even after the treatment with the combination of such low doses of OTA and FB1 that are daily human exposure in Europe (5 and 200 ng/kg b.w., respectively). Taken together these results confirm that the simultaneous exposure to different mycotoxins may have impact on human health.
endemic nephropathy; nephrotoxic mycotoxins; ochratoxin A; fumonisin B1; citrinin
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Podaci o prilogu
15-x.
2006.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Abstract Book Recent Advances in Endemic Nephropathy, Collegium Antropologicum
Čikeš, Nada ; Jelaković, Bojan
Zagreb: Hrvatsko andragoško društvo (HAD)
Podaci o skupu
Recent Advances in Endemic Nephropathy
pozvano predavanje
20.10.2006-22.10.2006
Zagreb, Hrvatska