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An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans (CROSBI ID 125890)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Bonassi, Stefano ; Znaor, Ariana ; Ceppi, Marcello ; Lando, Cecilia ; Chang, Wushou Peter ; Holland, Nina ; Kirsch-Volders, Micheline ; Zeiger, Errol ; Ban, Sadayuki ; Barale, Roberto et al. An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans // Carcinogenesis, 28 (2007), 3; 625-631-x

Podaci o odgovornosti

Bonassi, Stefano ; Znaor, Ariana ; Ceppi, Marcello ; Lando, Cecilia ; Chang, Wushou Peter ; Holland, Nina ; Kirsch-Volders, Micheline ; Zeiger, Errol ; Ban, Sadayuki ; Barale, Roberto ; Bigatti, Maria Paola ; Bolognesi, Claudia ; Cebulska-Wasilewska, Antonina ; Fabianova, Eleonora ; Fučić, Alexandra ; Hagmar, Lars ; Jokšić, Gordana ; Martelli, Antonietta ; Migliore, Lucia ; Mirkova, Ekaterina ; Scarfi, Maria Rosaria ; Zijno, Andrea ; Norppa, Hannu ; Fenech, Michael

engleski

An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans

The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker of chromosomal damage and genome stability in human populations. Much theoretical evidence has been accumulated supporting the causal role of MN induction in cancer development, although prospective cohort studies are needed to validate MN as a cancer risk biomarker. A total of 6, 718 subjects from of 10 countries, screened in 20 laboratories for MN frequency between 1980 and 2002 in ad hoc studies or routine cytogenetic surveillance, were selected from the database of the HUman MicroNucleus (HUMN) international collaborative project and followed up for cancer incidence or mortality. To standardize for the inter-laboratory variability subjects were classified according to the percentiles of MN distribution within each laboratory as Low, Medium, or High frequency. A significant increase of all cancers incidence was found for subjects in the groups with Medium (RR=1.84 ; 95% CI: 1.28-2.66) and High MN frequency (RR=1.53 ; 1.04-2.25). The same groups also showed a decreased cancer-free survival, i.e., p=0.001 and p=0.025, respectively. This association was present in all national cohorts and for all major cancer sites, especially urogenital (RR=2.80 ; 1.17-6.73) and gastro-intestinal cancers (RR=1.74 ; 1.01-4.71). The results from the present study provide preliminary evidence that MN frequency in PBL is a predictive biomarker of cancer risk within a population of healthy subjects. The current wide-spread use of the MN assay provides a valuable opportunity to apply this assay in the planning and validation of cancer surveillance and prevention programs.

micronucleus; cancer

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Podaci o izdanju

28 (3)

2007.

625-631-x

objavljeno

0143-3334

Povezanost rada

Javno zdravstvo i zdravstvena zaštita

Indeksiranost