engleski

The lenght of period of active disease as predictor of decreasing bone mineral density in patients with inflammatory bowel diseases

Introduction: The decrease in bone mineral density (BMD) is a well known problem in patients with inflammatory bowel diseases: Crohn's disease and ulcerative colitis Aim: To determine the correlation between the use of corticosteroid therapy, the lenght of period of active diesease with the bone mineral density in patients with inflammatory bowel disease Patients and methods: In our study 92 patients were included: 60 patients with Crohn's disease and 32 with ulcerative colitis. The data about disease duration, the lenght of periods of active disease corticosteroid therapy were taken from the database of patients with inflammatory bowel diseases. Using CDAI (Crohn's disease activity index) and CAI ( Colitis activity index) we determined the period of active disease which was verified in 30 patients with Crohn's disease and 20 patients with ulcerative colitis. Lumbar and femoral neck bone mineral densities were measured by dual energy x-ray apsorptiometry. Statistical evaluation of data was performed using StatSoft, Inc. Results: Osteopenia was found in 14 (43%) patients with ulcertive colitis and 24 patients (40 %) with Crohn's disease. Four patients (12%) with ulcerative colitis and 7 (11%)patients with Crohn's disease have osteoporosis. Analysis of bone density (lumbar and hip T and Z score) by multiple regression analysis showed a statistically significant correlation with the duration of active disease (p<0, 001 for hip T and Z score, p=0, 001 for spine T score 0, 003and 0, 002 for spine Z score). Conclusion: To adjust for possible counfounding of CS therapy to the correlation of bone parameters with disease duration, we performed a multiple regression analysis that has showed the overall disease duration as much bettter predictor of bone reducement in comparison of CS therapy duration.

inflammatory bowel disease; disease activity; Crohn&#8217; s disease; ulcerative colitis; osteopenia; osteoporosis.

DOI: 10.1007/s00223-006-6003-y