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Patients with rheumatoid arthritis have higher expression of BMP-6 in the peripheral blood mononuclear cells compared with patients with spondyloarthritis (CROSBI ID 521119)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Grčević, Danka ; Topić, Iva ; Kovačić, Nataša ; Jajić, Zrinka ; Ivčević, Sanja ; Grubišić, Fran ; Katavić, Vedran ; Marušić, Ana Patients with rheumatoid arthritis have higher expression of BMP-6 in the peripheral blood mononuclear cells compared with patients with spondyloarthritis // 6th International Conference on Bone Morphogenetic Proteins : Abstract Book. Zagreb, 2006. str. 129-129

Podaci o odgovornosti

Grčević, Danka ; Topić, Iva ; Kovačić, Nataša ; Jajić, Zrinka ; Ivčević, Sanja ; Grubišić, Fran ; Katavić, Vedran ; Marušić, Ana

engleski

Patients with rheumatoid arthritis have higher expression of BMP-6 in the peripheral blood mononuclear cells compared with patients with spondyloarthritis

Rheumatoid arthritis (RA) is an autoimmune disease characterized by proliferation of inflamed synovial membrane and bone destruction. In spondyloarthritis (SpA), inflammation and excessive reparative responses may lead to inappropriate cartilage and bone formation, causing joint ankylosis. The aim of our study was to test changes in the expression of selected BMPs in the peripheral blood mononuclear cells (PBMC) of patients with RA and SpA. Blood samples were collected from SpA patients, either with ankylosing spondylitis (AS ; n = 10) or psoriatic arthritis (PA ; n = 13), and RA patients (n = 10). cDNA was extracted from PBMCs, amplified by quantitative PCR using TaqMan assays (Applied Biosystems) for BMP-2 and BMP-6, and expressed as the relative amounts of RNA (mean ± SD) for target genes normalized to GPDH, using the standard curve method. The expression of BMP-2 was similar in all patients, whereas the expression of BMP-6 was significantly higher in RA than in both types of SpA PBMC samples (1.3 ± 0.7 in RA vs. 0.7 ± 0.4 in PA and 0.7 ± 0.3 in AS, ANOVA, p = 0.03). Our preliminary results indicate that RA, as a chronic inflammatory disease, has increased expression of BMP-6, which may reflect the systemic activation of inflammatory calls and lymphocytes, in contrast to SpA. Our further aim is to test the expression of other BMPs, their receptors, signaling molecules, and antagonists in a larger number of patients with different chronic joint diseases and correlate them with the disease parameters.

rheumatoid arthritis; spondyloarthritis; BMP-6; gene expression

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Podaci o prilogu

129-129.

2006.

objavljeno

Podaci o matičnoj publikaciji

6th International Conference on Bone Morphogenetic Proteins : Abstract Book

Zagreb:

Podaci o skupu

International Conference on Bone Morphogenetic Proteins (6 ; 2006)

poster

11.10.2006-15.10.2006

Cavtat, Hrvatska

Povezanost rada

Temeljne medicinske znanosti