engleski

PDT protocol improvements in treatment of Actinic Keratosis and Bowen's Disease

Topical photodynamic therapy (PDT) is a highly effective treatment for several skin tumors as Actinic Keratoses, Bowen's Disease, Superficial Basal Cell Carcinoma and other pre-malignant diseases. Treatment is well tolerated and can be performed on outpatient basis. In one-year period on Outpatient department of dermatology, 20 patients were treated with topical PDT. The light source was MEDILED-4 PDD & PDT system. Biopsies were performed prior and one month after the PDT treatment. Indications were solely actinic keratosis and Bowen's disease. One group of patients (four women and six males) was PDT treated 4 hours after administration of 20% 5-aminolaevulinic acid cream (ALA). The delivered light dose of 75 J/cm2 resulted in low clearance rates what was confirmed by histopathological findings. The second group of patients (two women and eight males) was treated with PDT 16 hours after 5-ALA administration. The total illumination dose was 100 J/cm2 with interruption of 30 minutes after received 50 J/cm2. The latter protocol showed much higher efficiency in tumors' eradication and all patients in our clinics are now being successfully treated using the new protocol.

photodynamic diagnosis; photodynamic therapy

nije evidentirano