engleski

The comparasion between liver and gastric lesion in restraint stress

Liver lesions induced by severe stress are morpfologically well defined. Different stressors have been used to invastigete the pattern and dynamics of stress induced liver damage, but according to our knowledge the model of immobilization stress has not yet been employed. The immobilization stress represents a stress inducing model thought to include mostly psychological injury, thus differing from other-purly physical models. The stomach is one the best known, and mostly investigated target organs in stress. In our study we were comparing restraint-stres induced lesion in the liver and in the stomach. As expected, in the stomach we found a time-related aggravitation of lesions, while the liver lesion followed an unexpected course. The stress-induced fatty change in the hepatocytes was consinstently less prounonced in animals exposed to stress during 48 hours, as compared with those exposed for 24 hours.The possible mechanisms of this unexpected finding , however, remains unknown. Therefore, the observed differences between the stomach and liver restraint stress lesions development as well as the involved mechanisms will be subject of further investigation.

restraint stress; liver lesion; gastric lesions

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