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Autoimmune blistering diseases - yesterday, today, tomorrow

Autoimmune blistering diseases are group of diseases which include many different dermatoses. Lever in 1953 made first differentiation between pemphigus and pemphigoid group of diseases, based on level of separation in the skin. Introducing immunofluorescence techniques in 1979 in diagnostic algorithm of blistering diseases led to a great progress in understanding of the biology of these disease, to more accurate classification and diagnosis. Immunofluorescence studies are mainstay of diagnosis of autoimmune bullous diseases today. Expansion of molecular biology revealed a number of target antigens with related genes. Future studies and development of new diagnostic procedures will provide a better understanding of immune mechanisms involved in the pathogenesis of these diseases with attempts to gain a more specific therapy based on specific modulations of immune system.

autoimmune blistering diseaes; diagnostic algorithm

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