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Expression of BMPs in adult human osteophyte tissue (CROSBI ID 521931)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Zoričić, Sanja ; Marić, Ivana ; Šantić, Veljko ; Bobinac, Dragica ; Vukičević, Slobodan Expression of BMPs in adult human osteophyte tissue // Bone (New York, N.Y.) / Baron, Roland (ur.). 2001. str. S109-S109

Podaci o odgovornosti

Zoričić, Sanja ; Marić, Ivana ; Šantić, Veljko ; Bobinac, Dragica ; Vukičević, Slobodan

engleski

Expression of BMPs in adult human osteophyte tissue

Osteoarthrisis is characterized by focal cartilage destruction and marked formation of osteophytes. This study was performed on a series of 25 osteophytes removed from the knee and hip joint during joint replacement surgery. Ostophyteswere recognized as a small overhanging lips located usually at the margin of articular surface. Specimens were fixed in 4% PFA, undecalcified embedded in MMA and cut serially at 200 mm intervals on 4 mm thick slices. The mechanism of osteophyte formation was examined histologically and immunohistochemically, utilizing specific antibodies for bone morphogenetic proteins (BMPs). Histological analysis revealed loose fibrous tissue on osteophyte's surface and transitional zone of fibrocartilage beneath it. The zone of hyaline cartilage faced to fibrocartilage and showed typical morphology of articular cartilage such as arrangement of cartilage zones and cartilage matrix staining pattern by toluidine blue and safranine O. Osteophytes hyaline cartilage have not contained tide mark line but it had contained large chondrocyte clusters. On the eroded cartilage surface invaded by blood vessels, a mass of osteoclastic and mononuclear cells were visible as well as numerous deposited osteoblasts and osteocytes embedded in osteoid. Fibrous tissue close to bone trabeculae was observed either on surface of osteophytes or within areas of active bone remodeling in osteophytes. BMPs were immunohistochemically observed in: 1) hypertrophic chondrocytes (BMP-3, and – 7), 2) osteoblasts (BMP-2, -3, -5, and – 7), 3) osteocytes (BMP-3, -6, and – 7), 4) bone matrix (BMP-3, -6, and – 7), 4) cartilage matrix (BMP-3), and 5) fibrous tissue matrix (BMP-2, and – 3). In a typical osteophyte the arrangement of all zone followed normal cellular events present in endochondral and/or intramembranous bone formation. The pattern of BMPs in osteophytes tissue suggests that members of the BMP family may have a specific role in formation of osteophytes removed from osteoarthritic joints.

bone morphogenetic proteins; osteophytes; humans; immunohistochemistry

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Podaci o prilogu

S109-S109.

2001.

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objavljeno

Podaci o matičnoj publikaciji

Bone (New York, N.Y.)

Baron, Roland

New York (NY): Elsevier

8756-3282

Podaci o skupu

1st Joint Meeting of the International Bone and Mineral Society and the European Calcified Tissue Society

poster

05.06.2001-10.06.2001

Madrid, Španjolska

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost