Immunocomplex deposits in the skin of patients with multiple sclerosis (CROSBI ID 469915)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Matijaca, Meri ; Reić, Petar ; Marović, Anton ; Pavelin, Slobodan ; Sepčić, Juraj
engleski
Immunocomplex deposits in the skin of patients with multiple sclerosis
In a group of 72 multiple sclerosis, MS, patients immunocomplex deposits at the dermal-epidermal junction were determined. Our aim was to compare the immunopathologic diagnosis based on a direct immunofluorescence, DIF, with clinical findings in these patients. Skin biopsy and DIF were performed according to Cormane method which was slighly modified by Gligora. Rabbit anti-human IgG, IgA, IgM and C3 antibodies were used. The youngest patient was 16 years old and the oldest was 52 years old, showing a female prevalence, 77.8 percent. DIF findings were negative for anti IgG antibodies in 59,7 percent, for anti IgA antibodies in 43 percent, for anti IgM antibodies in 18 percent, for anti C3 antibodies in 78 percent. Fluorescence of granular immunocomplex deposits on the dermal-epidermal junction was positive for anti IgG antibodies in 20,8 percent, for anti IgA antibodies in 50 percent, for anti IgM antibodies in 74 percent, for C3 antibodies in 9,7 percent. Clot forming fluorescence findings were positive for anti IgG antibodies in 15,3 percent, for anti IgA antibodies in 7 percent, for anti IgM antibodies in 8 percent, for anti C3 antibodies in 11 percent. DIF showed positive fluorescence of capillaries for anti IgG antibodies in 2,8 percent and for C3 antibodies in 1,3 percent. DIF showed positive fluorescence of citobodies for anti IgG antibodies in 1,4 percent. Results sugest that the most inportant findings were fluorescence of anti IgM antibodies forming granular immunocomplex deposits.
Multiple sclerosis; Immunocomplex; Immunofluorescence-direct
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nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
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Podaci o prilogu
286-x.
1998.
objavljeno
Podaci o matičnoj publikaciji
Multiple sclerosis Clinical and Laboratory Research
Allen, Ingrid V.
Avenel (NJ): Stockton press
Podaci o skupu
ECTRIMS 98 14th Congress of the European Committee for Treatment and Research in Multiple Sclerosis
poster
09.09.1998-12.09.1998
Stockholm, Švedska