engleski

Bone morphogenetic protein-7 expression in tumoral calcinosis and brown tumor of secondary hyperparathyroidism

Bone morphogenetic proteins (BMPs) are family of multifunctional growth and differentiation factors that were identified based on their ability to induce endochondral bone development at extraskeletal sites. A member of this family, BMP-7 acts locally and has predominant effect on bone cell growth and tissue differentiation. In the postnatal life, BMP-7 is expressed predominantly in kidney but it was also found in osteoblasts, bone matrix, periost, hypertrophic chondrocytes, centers of ossification and bone regeneration processes. Therefore, there is a potential possibility that BMP-7 could be involved in the pathogenesis of the renal osteodystrophy. BMPs were found in various pathological lesions in skeletal tissues such as myositis ossificans, fybrodysplasia ossificans progressiva, osteogenic sarcoma. We investigated tumoral cacification and brown tumor of secondary hyperparathyreodismus in patients with end-stage renal disease. The intention was to investigate BMP-7 protein expression in both types of osteodystrophic lesions. In both lesions, multinucleated giant osteoclast-like cells showed moderate cytoplasmic expression of BMP-7. Mononuclear stromal cells of brown tumor also express BMP-7. Within areas of bone resorption, there is a positive immunohistochemical reaction in cytoplasms of osteoblasts and bone matrix around osteocytes. Accordingly, we report another bone and soft tissue lesions with BMP-7 expression.

BMP-7; brown tumor; secundary hyperparathyrodism

nije evidentirano