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Exposure to hyperbaric pressure alters ganglioside expression in rat liver following partial hepatectomy (CROSBI ID 522550)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Čikeš Čulić, Vedrana ; Kurir Tičinović, Tina ; Radić, S. ; Zemunik, Tatijana ; Mesarić, M. ; Markotić, Anita Exposure to hyperbaric pressure alters ganglioside expression in rat liver following partial hepatectomy // The FEBS journal / Perham, Richard (ur.). 2006. str. 264-264

Podaci o odgovornosti

Čikeš Čulić, Vedrana ; Kurir Tičinović, Tina ; Radić, S. ; Zemunik, Tatijana ; Mesarić, M. ; Markotić, Anita

engleski

Exposure to hyperbaric pressure alters ganglioside expression in rat liver following partial hepatectomy

Remnant liver after partial hepatectomy (PH) demands an increased amount of oxygen to restore hepatic energy. Modulation of the ganglioside content of hepatocyte plasma membrane could provide a mean for upregulating cellular responsiveness to a variety of factors. Rat liver gangliosides were analysed by high performance thin layer chromatography (HPTLC) followed with immunostaining 54 h after PH. Non-operated and three different groups of operated rats were studied according to the hausing conditions before or after operation: recovering under normal ambient conditions after operation (1), treating with hyperbaric pressure before operation and recovering under normal ambient conditions (2 or preHB), and recovering under hyperbaric pressure after operation (3 or postHB). Liver of preHB group showed the highest expression of ganglioside GD1a, a marker of a peculiar transition phase of liver regeneration. Same animals showed enhanced expression of the several gangliosides: GM2, GM1a, GD1b, GT1b, Gal-NAcGM1b, nLc4, nLc6 and nLc8. Since galactosyl- and N-acetylgalactosaminyltransferase catalyse final step of synthesis of GM2, GM1a, GD1b, Gal-NAcGM1b, nLc4, nLc6, and nLc8, our results point at possible role of galactosyl- and N-acetylgalactosaminyltransferase in regulation of the liver growth after PH.

hyperbaric oxygenation; liver regeneration; gangliosides

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Podaci o prilogu

264-264.

2006.

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objavljeno

Podaci o matičnoj publikaciji

The FEBS journal

Perham, Richard

Oxford: Wiley-Blackwell

1742-464X

Podaci o skupu

31st FEBS Congress "Molecules in Health and Disease"

poster

24.06.2006-29.06.2006

Istanbul, Turska

Povezanost rada

Kemija, Temeljne medicinske znanosti

Indeksiranost