engleski

Evaluation of the inactivated water-in-oil-in water vaccine against porcine parvovirosis (Parvokal)

Porcine parvovirus (PPV) is widespread througout the world and in each country numerous herds are infected. PPV is a major cause of reproductive failure in pigs characterized by embryonic and fetal infection and death, usually in the absence of outward matemal clinical signs (1,2,3). The pigs can be effetively protected by acitve immunization. Widely used inactivated vaccines are prepared mostly in the form of a water-in-oil emulsion (WOE). Unfortunately. The WOE vaccines are viscous, difficult to inject and occasionally cause excessive tissue reactions at the site of inoculation. Aqueous-phase surfactants, like the nonionic detergent Tween 80 (polyaxyethylene sorbitan monooleate), in combination with oil-phase surfactants, diminish the viscosity of the WOE vaccines and form smalldroplet stabile emulsion. This study describes the efficacy of the new inactivated vaccine against porcine parvovirosis prepared in the form of a water-in-oil-in-water emulsion (WOWE).

porcine parvovirosis; vaccination

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