IL-18 and TNF-α promoter polymorphisms and susceptibility to type 1 diabetes in the Dalmatian population (CROSBI ID 522773)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Boraska, Vesna ; Bečić, Kristijan ; Škrabić, Veselin ; Peruzović, Marijana ; Čikeš Čulić, Vedrana ; Kapitanović, Sanja ; Zemunik, Tatijana
engleski
IL-18 and TNF-α promoter polymorphisms and susceptibility to type 1 diabetes in the Dalmatian population
Type 1 diabetes mellitus (T1DM) is characterized by a chronic progressive inflammatory autoimmune reaction that causes the selective elimination of pancreatic β cells. Proinflammatory cytokines, interleukin-18 (IL-18) and tumor necrosis factor alpha (TNF-α ), both have been implicated in the pathogenesis of T1DM. Additionally IL-18 plays a role in regulation of TNF-α production. Therefore we tested an association of two single nucleotide polymorphisms (SNP) in promoter regions of these genes with the susceptibility to T1DM in the Dalmation population (South Croatia). 134 T1DM patients and 132 control subjects were tested for a G-137C change in a promoter region of IL-18 gene by a sequence specific PCR. TNF-α G-308A promoter variant was genotyped in a larger group of T1DM patients (206) and controls (144) by standard PCR followed with NcoI endonuclease restriction. Data were analysed using chi-square test. A distribution of IL-18 G-137C and TNF-α G-308A promoter variants was equal between the T1DM patients and the controls (p=0.9448 and p=0.0655, respectively). The present study provided no evidence of association of IL-18 and TNF-α promoter variants with susceptibility to T1DM in Dalmatian population. However as genotype frequencies for TNF-α G-308A polymorphism were close to the limit of statistical significance (p=0.0655) further analysis should be conducted.
IL-18; TNF-alpha; type 1 diabetes; Dalmatia
European Journal of Human Genetics (ISSN 1018-4813)
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Podaci o prilogu
332-332.
2006.
objavljeno
Podaci o matičnoj publikaciji
European Human Genetics Conference 2006 : abstracts
European Society of Human Genetics
Amsterdam: Nature publishing group
Podaci o skupu
European Human Genetics Conference 2006
poster
06.05.2006-09.05.2006
Amsterdam, Nizozemska