S6-deficiency activates a p53-dependent checkpoint (CROSBI ID 523048)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Volarević, Siniša
engleski
S6-deficiency activates a p53-dependent checkpoint
Nascent ribosome biogenesis is required during cell growth. To gain insight into importance of this process during mouse oogenesis and embryonic development, we deleted one allele of the ribosomal protein S6 gene in growing oocytes and generated S6-heterozygous embryos. Oogenesis and embryonic development until E5.5 were normal. However, inhibition of entry into M phase of the cell cycle and apoptosis became evident post E5.5, leading to peri-gastrulation lethality. Genetic inactivation of p53 bypassed this checkpoint and prolonged development until E12.5, when they die with defective translation of D-type cyclins and erythropoiesis. Thus, a p53-dependent checkpoint is activated during gastrulation in response to ribosome insufficiency in order to prevent improper execution of the developmental program.
ribosome; ribosomal protein S6 gene; mouse embryonic development; p53 protein
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
2006.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
Federation of European Cancer Societies
pozvano predavanje
30.06.2006-03.07.2006
Budimpešta, Mađarska