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Pregled bibliografske jedinice broj: 275164

Časopis

Autori: Bulić-Jakuš, Floriana; Ulamec, Monika; Vlahović, Maja; Sinčić, Nino; Katušić, Ana; Jurić-Lekić, Gordana; Šerman, Ljiljana; Krušlin, Božo; Belicza, Mladen
Naslov: Of Mice and Men : Teratomas and Teratocarcinomas
Izvornik: Collegium antropologicum (0350-6134) 30 (2006), 4; 921-924
Vrsta rada: prikaz
Ključne riječi: teratoma; teratocarcinoma
Sažetak:
Teratomas and teratocarcinomas are tumors containing tissue derivatives of all three germ-layers. They can be induced by transplantation of animal embryos to ectopic microenvironment. Development of malignant teratocarcinomas depends on embryonic stage, species-specificity and immunological competence of the host. In the man, teratomas and teratocarcinomas usually represent a subtype of germ-cell tumors but sacrococcygeal teratomas arise from the remnants of the primitive streak. Undifferentiated embryonal carcinoma (EC) cells are responsible for the malignancy of experimental mouse teratocarcinomas. Mouse EC cells injected to the adult give rise to tumors and upon injection to early embryos to differentiated tissues thus resembling normal mouse embryonic stem cells (mESC). Epigenetic changes rather than mutations are associated with transformation of mESC to EC cells. Human EC and ES cell-lines (hESC) contain chromosomal abnormalities and can form teratocarcinoma. ES cells are among those proposed for cell therapy. Suicide gene introduction should be recomended prior to their use in vivo to ablate them in case of malignant transformation.
Projekt / tema: 0108049, 0108113, 0134002, 0108001
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
SCI-EXP, SSCI i/ili A&HCI
Current Contents Connect (CCC)
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
MEDLINE
Scopus
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=43595
URL cjelovitog teksta:
Google Scholar: Of Mice and Men : Teratomas and Teratocarcinomas



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