Modelling and Optimisation of Central Metabolism Response to Glucose Pulse (CROSBI ID 523292)
Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Čerić, Sonja ; Kurtanjek, Želimir
engleski
Modelling and Optimisation of Central Metabolism Response to Glucose Pulse
The application of global optimisation algorithms for modelling of enzyme kinetics and parameters of the central metabolism is analyzed. The model is a set of 10 highly complex stiff ordinary differential equations with 132 adaptive parameters. The efficacies of Nedler- Mead, simulated annealing, and differential evolution for minimization of variance between simulations of a model of the central metabolism and experimental data of the corresponding intracellular key metabolites are compared. Experimental data obtained during response of population of E. coli cultivated in a batch bioreactor are applied. Data are obtained during transients of 15 seconds upon a glucose impulse. Results are discussed in view of metabolic flux analysis and genetic engineering.
metabolic networks; Nedler-Mead; simulated annealing; differential evolution
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Podaci o prilogu
501-506-x.
2006.
objavljeno
Podaci o matičnoj publikaciji
Proceedings of Information Technology Interfaces, ITI 2006
Vesna, Lužar-Stiffler ; Vesna Dobrić-Hljuz
Zagreb: Sveučilišni računski centar Sveučilišta u Zagrebu (Srce)
Podaci o skupu
Inoformation Technology Interfaces 2006
predavanje
18.06.2006-22.06.2006
Cavtat, Hrvatska