engleski

The Role Of Neuroimaging Methods And Transcranial Color Doppler (Tcd) In Vascular(VaD) And Alzheimer Dementia (AD)

Recent studies have shown the VaD and AD might overlap in certain pathophysiological aspects. The aim of this study was to evaluate the role of neuroimaging methods and TCD in diagnostics of different kinds of dementia. Mean blood flow velocities (MBFV) were measured in right and left middle cerebral arteries (MCA) and in basilar artery (BA) in rest conditions by transcranial Doppler ultrasonography with a 2 MHz probe in two groups of patients: a) Alzheimer's disease (AD, N=43, age=72, 79 +/-8 years), b) patients with vascular dementia ( VaD, N=23, age=77, 43 +/- 7). The computerised tomography (CT) and magnetic resonance imaging (MRI) were performed in all patients. The results of CT and MR showed atrophy in 35 AD and 17 VD patients, the signs of hypoperfusion in 19 AD and 13 VD patients. Three AD and 4 VD patients had ischemic lesions while lacunar changes were found in 5 AD and 8 VD patients. No significant differences in MBFV measured by TCD have been detectable between patients with AD and VD. TCD is convenient method for evaluation of intracerebral hemodynamic, however in settings of dementia. TCD has not shown to be reliable method for differentiation between Alzheimer and vascular type of dementia. Due to a high prevalence of lacunar changes on CT and MR in both AD and VaD, current research in our laboratory is focused on the role of TCD emboli monitoring in pathophysiology of these types of dementia.

TCD; dementia; neuroimaging

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